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1.
Bull Math Biol ; 86(5): 51, 2024 Apr 06.
Artículo en Inglés | MEDLINE | ID: mdl-38581579

RESUMEN

Forest plantations are economically and environmentally relevant, as they play a key role in timber production and carbon capture. It is expected that the future climate change scenario affects forest growth and modify the rotation age for timber production. However, mathematical models on the effect of climate change on the rotation age for timber production remain still limited. We aim to determine the optimal rotation age that maximizes the net economic benefit of timber volume in a negative scenario from the climatic point of view. For this purpose, a bioeconomic optimal control problem was formulated from a system of Ordinary Differential Equations (ODEs) governed by the state variables live biomass volume, intrinsic growth rate, and area affected by fire. Then, four control variables were associated to the system, representing forest management activities, which are felling, thinning, reforestation, and fire prevention. The existence of optimal control solutions was demonstrated, and the solutions of the optimal control problem were also characterized using Pontryagin's Maximum Principle. The solutions of the model were approximated numerically by the Forward-Backward Sweep method. To validate the model, two scenarios were considered: a realistic scenario that represents current forestry activities for the exotic species Pinus radiata D. Don, and a pessimistic scenario, which considers environmental conditions conducive to a higher occurrence of forest fires. The optimal solution that maximizes the net benefit of timber volume consists of a strategy that considers all four control variables simultaneously. For felling and thinning, regardless of the scenario considered, the optimal strategy is to spend on both activities depending on the amount of biomass in the field. Similarly, for reforestation, the optimal strategy is to spend as the forest is harvested. In the case of fire prevention, in the realistic scenario, the optimal strategy consists of reducing the expenses in fire prevention because the incidence of fires is lower, whereas in the pessimistic scenario, the opposite is true. It is concluded that the optimal rotation age that maximizes the net economic benefit of timber volume in P. radiata plantations is 24 and 19 years for the realistic and pessimistic scenarios, respectively. This corroborates that the presence of fires influences the determination of the optimal rotation age, and as a consequence, the net economic benefit.


Asunto(s)
Incendios , Bosques , Incendios/prevención & control , Conceptos Matemáticos , Modelos Biológicos
2.
Value Health ; 2024 Mar 09.
Artículo en Inglés | MEDLINE | ID: mdl-38462224

RESUMEN

OBJECTIVES: Health technology assessment (HTA) guidance often recommends a 3% real annual discount rate, the appropriateness of which has received limited attention. This article seeks to identify an appropriate rate for high-income countries because it can influence projected cost-effectiveness and hence resource allocation recommendations. METHODS: The author conducted 2 Pubmed.gov searches. The first sought articles on the theory for selecting a rate. The second sought HTA guidance documents. RESULTS: The first search yielded 21 articles describing 2 approaches. The "Ramsey Equation" sums contributions by 4 factors: pure time preference, catastrophic risk, wealth effect, and macroeconomic risk. The first 3 factors increase the discount rate because they indicate future impacts are less important, whereas the last, suggesting greater future need, decreases the discount rate. A fifth factor-project-specific risk-increases the discount rate but does not appear in the Ramsey Equation. Market interest rates represent a second approach for identifying a discount rate because they represent competing investment returns and hence opportunity costs. The second search identified HTA guidelines for 32 high-income countries. Twenty-two provide no explicit rationale for their recommended rates, 8 appeal to market interest rates, 3 to consistency, and 3 to Ramsey Equation factors. CONCLUSIONS: Declining consumption growth and real interest rates imply HTA guidance should reduce recommended discount rates to 1.5 to 2+%. This change will improve projected cost-effectiveness for therapies with long-term benefits and increase the impact of accounting for long-term drug price dynamics, including reduced prices attending loss of market exclusivity.

3.
J Environ Manage ; 355: 120525, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38437743

RESUMEN

Activated carbon (AC), renowned for its versatile applications in water treatment, air purification, and industrial processes, is a critical component in environmental remediation and resource recovery strategies. This study encompasses the process modeling of AC production using anthracite coal as a precursor, involving multiple activation stages at different operating conditions, coupled with a detailed techno-economic analysis aimed at assessing the operational feasibility and financial viability of the plant. The economic analysis explores the investigation of economic feasibility by performing a detailed cashflow and sensitivity analysis to identify key parameters influencing the plant's economic performance, including raw material and energy prices, operational and process parameters. Capital and operational costs are meticulously evaluated, encompassing raw material acquisition, labor, energy consumption, and equipment investment. Financial metrics like Net Present Value (NPV), Internal Rate of Return (IRR), and payout period (POP) are employed, and the results show that AC selling price, raw material cost and plant capacity are the most influential parameters determining the plant's feasibility. The minimum AC production cost of 1.28 $/kg is obtained, corresponding to coal flow rate of 14,550 kg/h. These findings provide valuable insights for stakeholders, policymakers, and investors seeking to engage in activated carbon production from anthracite.


Asunto(s)
Carbón Orgánico , Restauración y Remediación Ambiental , Carbón Mineral , Inversiones en Salud , Plantas
4.
Waste Manag ; 174: 203-217, 2024 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-38061188

RESUMEN

Medical waste (MW) is exploding due to the COVID-19 pandemic, posing a significant environmental threat, and leading to the urgent requirement for affordable and environmentally friendly MW disposal technologies. Prior research on individual MW disposal plants is region-specific, applying these results to other regions may introduce bias. In this study, major MW disposal technologies in China, i.e., incineration technologies (pyrolysis incineration and rotary kiln incineration), and sterilization technologies (steam sterilization, microwave sterilization, and chemical disinfection) with residue landfill or incineration were analyzed from an industry-level perspective via life cycle assessment (LCA), life cycle costing (LCC) and net present value (NPV) methods. Life cycle inventories and economic cost data for 4-5 typical companies were selected from 128 distinct enterprises and academic sources for each technology. LCA results show that microwave sterilization with residue incineration has the lowest environmental impact, emitting only 480 kg CO2 eq. LCC and NPV analyses indicate that steam sterilization with landfilling is the most economical, yielding revenues of 1,210 CNY/t and breaking even in the first year. Conversely, pyrolysis and rotary kiln incineration break even between the 4th and 5th years. Greenhouse gas emissions from the MW disposal in ten cities with the largest MW production in 2020 increased by 7% over 2019 to 43,800 tons and other pollutants increased by 6% to 12%. Economically, Shanghai exhibits the highest cost-effectiveness, while Nanjing delivers the lowest. It can be observed that the adoption of optimal environmental technologies has resulted in a diminution of greenhouse gas emissions by 279,000 tons and energy conservation of 1.76 billion MJ.


Asunto(s)
Gases de Efecto Invernadero , Eliminación de Residuos Sanitarios , Residuos Sanitarios , Eliminación de Residuos , Administración de Residuos , Humanos , Eliminación de Residuos Sanitarios/métodos , Ciudades , Vapor , Análisis Costo-Beneficio , Pandemias , China , Incineración/métodos , Instalaciones de Eliminación de Residuos , Eliminación de Residuos/métodos , Administración de Residuos/métodos
5.
J Surg Res ; 291: 527-535, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37540970

RESUMEN

INTRODUCTION: Surgical residents make decisions that may have a dramatic impact on career earnings based off conceptions regarding future income potential. This study examines the effect of debt burden, repayment plan, and practice setting on a general surgeon's career value. METHODS: Debt levels, repayment plans, and practice setting were considered to model a surgeon's career value using net present value (NPV) across 35 scenarios. The NPV was calculated using salary, education debt, yearly spending, and a discount rate of 5%. Salary data were obtained from the Medical Group Management Association, student debt information from the Association of American Medical Colleges, and tax and household spending data from U.S. government records. Assumptions included no gaps in training, no prior debt, single-person household, and career duration of 35 y. RESULTS: A general surgeon's salary adequately repays debt burdens from $100,000-$300,000 over 10-25 y, regardless of repayment plan or practice setting. Practice setting decreased career value for academic surgeons when debt burden and repayment plan were held constant: the NPV for an academic surgeon was $382,000 compared to $500,000 for a nonacademic surgeon with the same debt and repayment plan. Debt burden repaid through unsubsidized and income-based repayment plans reduced NPV for all surgeons, while subsidized plans increased NPV. The projected NPV for all scenarios ranged $2.35M-$2.87 M. CONCLUSIONS: Though the modeled scenarios do not account for prior debt burden, major expenditures, or increases in yearly household spending beyond national averages, surgery residents should be aware that general surgery remains a financially feasible career.


Asunto(s)
Internado y Residencia , Cirujanos , Humanos , Selección de Profesión , Renta , Salarios y Beneficios
6.
Poult Sci ; 102(4): 102507, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36805393

RESUMEN

Smaller scale agricultural production for food, income, and as a hobby is a growing trend among United States (US) producers. Laying hens or quail are an economically viable livestock enterprise for small-scale producers with limited resources. In this study, we evaluated the economic feasibility of small-scale egg production (1,000 birds) and compared the profitability under 3 different production systems, and 2 price scenarios. The cost-benefit analysis in this study encompasses calculating and simulating all costs and returns associated with chicken and quail production over a 10-yr period. Two prices were evaluated, farm gate prices that US commercial producers face, and US farmers' market prices more often faced by small-scale producers. In all 3 production scenarios (chicken with the option of natural molting, chicken without molting, and raising quail) small-scale egg production is economically viable when farmers' market egg prices were used to calculate the Net Present Value (NPV). Using farmers' market prices, raising quail has the highest NPV. Raising chickens without molting has the second highest NPV, while raising chickens and allowing them to undergo molting has the lowest NPV. Contrarily, when farm gate egg prices are used in the estimation, only raising quail had a positive NPV. Although the quail enterprise resulted in the highest NPV under both price conditions, there may be marketing difficulties based on the producer's location. Producers located near cities, or Asian populations where quail eggs are more popular may be successful with small-scale quail operations.


Asunto(s)
Pollos , Codorniz , Animales , Femenino , Granjas , Óvulo , Agricultura , Coturnix
7.
Heliyon ; 9(1): e12902, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36685476

RESUMEN

This paper presents the technical, financial, and environmental impact assessment of a 50-MW (MW) utility-scale wind farm in Ghana at four locations: Anloga, Atiteti, Sege, and Denu. The monthly average wind speeds recorded at the locations were 6.01 m/s, 5.98 m/s, 5.46 m/s, and 5.17 m/s respectively at 60 m above ground level. Capacity factors of 24.9%, 24.4%, 20.6%, and 18.0% were obtained at the locations respectively. The Net Present Value (NPV) was the main financial metric employed to determine the viability of the projects. The results indicated that a potential utility-scale wind project is viable at all locations under study. Furthermore, the Electricity Exported to the Grid and the Electricity Export Rate (EER) had the highest impact of 0.63 and 0.62 on the NPV respectively and therefore these key parameters should be well considered before any potential project implementation.

8.
Environ Resour Econ (Dordr) ; 84(2): 343-381, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36712582

RESUMEN

Given the drastic changes in the environment, resilience is a key focus of ecosystem management. Yet, the quantification of the different dimensions of resilience remains challenging, particularly for long-lived systems such as forests. Here we present an analytical framework to study the economic resilience of different forest management systems, focusing on the rate of economic recovery after severe disturbance. Our framework quantifies the post-disturbance gain in the present value of a forest relative to a benchmark system as an indicator of economic resilience. Forest values and silvicultural interventions were determined endogenously from an optimization model and account for risks affecting tree survival. We consider the effects of differences in forest structure and tree growth post disturbance on economic resilience. We demonstrate our approach by comparing the economic resilience of continuous cover forestry against a clear fell system for typical conditions in Central Europe. Continuous cover forestry had both higher economic return and higher economic resilience than the clear fell system. The economic recovery from disturbance in the continuous cover system was between 18.2 and 51.5% faster than in the clear fell system, resulting in present value gains of between 1733 and 4535 € ha-1. The advantage of the continuous cover system increased with discount rate and stand age, and was driven by differences in both stand structure and economic return. We conclude that continuous cover systems can help to address the economic impacts of increasing disturbances in forest management.

9.
Ther Innov Regul Sci ; 57(2): 209-219, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-36104654

RESUMEN

BACKGROUND: Deployment of remote and virtual clinical trial methods and technologies, referred to collectively as decentralized clinical trials (DCTs), represents a profound shift in clinical trial practice. To our knowledge, a comprehensive assessment of the financial net benefits of DCTs has not been conducted. METHODS: We developed an expected net present value (eNPV) model of the cash flows for new drug development and commercialization to assess the financial impact of DCTs. The measure of DCT value is the increment in eNPV that occurs, on average, when DCT methods are employed in comparison to when they are not. The model is populated with parameter values taken from published studies, Tufts CSDD benchmark data, and Medable Inc. data on DCT projects. We also calculated the return on investment (ROI) in DCTs as the ratio of the increment in eNPV to the DCT implementation cost. RESULTS: We found substantial value from employing DCT methods in phase II and phase III trials. If we assume that DCT methods are applied to both phase II and phase III trials the increase in value is $20 million per drug that enters phase II, with a seven-fold ROI. CONCLUSIONS: DCTs can provide substantial extra value to sponsors developing new drugs, with high returns to investment in these technologies. Future research on this topic should focus on expanding the data to larger datasets and on additional aspects of clinical trial operations not currently measured.


Asunto(s)
Ensayos Clínicos como Asunto , Desarrollo de Medicamentos , Desarrollo de Medicamentos/economía , Ensayos Clínicos como Asunto/economía
10.
J Environ Manage ; 326(Pt A): 116679, 2023 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-36403320

RESUMEN

Despite significant drop in pollinator abundance, no studies exist on the benefits and costs of pollinator conservation in the public domain. An in-person survey was conducted at three large, public US universities to estimate benefits to become Bee Campus USA certified. We test whether different types of reminders on existing student sustainability fees affect Willingness to Pay. Costs of achieving this certification per university were obtained. Net Present Value demonstrates that the net benefits to each school are largely positive, except under the most restrictive assumption. Information reminders of existing fees lead to little change in support of pollinator conservation.


Asunto(s)
Crianza de Animales Domésticos , Certificación , Análisis Costo-Beneficio , Animales , Abejas , Certificación/economía , Sector Público , Universidades/economía , Crianza de Animales Domésticos/economía , Crianza de Animales Domésticos/legislación & jurisprudencia , Polinización
11.
J Environ Manage ; 325(Pt A): 116468, 2023 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36419299

RESUMEN

The number of micro-scale spirit distilleries worldwide has grown considerably over the past decade. With an onus on the distillery sector to reduce its environmental impact, such as carbon emissions, opportunities for increasing energy efficiency need to be implemented. This study explores the potential environmental benefits and financial gains achievable through heat recovery from different process and by-product streams, exemplified for a Scotch whisky distillery, but transferrable to micro-distilleries worldwide. The eco-efficiency methodology is applied, taking into account both climate change and water scarcity impacts as well as economic performance of alcohol production with and without heat recovery. A Life Cycle Assessment, focusing on climate change and water scarcity, is combined with a financial assessment considering investment costs and the present value of the savings over the 20-year service life of the heat recovery system. The proposed heat recovery systems allow carbon emission reductions of 8-23% and water scarcity savings of 13-55% for energy and water provision for 1 L of pure alcohol (LPA). Financial savings are comparatively smaller, at 5-13%, due to discounting of the future savings - but offer a simple payback of the investment costs in under two years. The eco-efficiency of the distillery operations can be improved through all proposed heat recovery configurations, but best results are obtained when heat is recovered from mashing, distillations and by-products altogether. A sensitivity analysis confirmed that the methodology applied here delivers robust results and can help guide other micro-distilleries on whether to invest in heat recovery systems, and/or the heat recovery configuration. Uptake should be enhanced through increased information and planning support, and in cases where the distillery offers insufficient heat and water sinks to use all pre-warmed water, opportunities to link with a heat sink outside the distillery are encouraged. A 10% reduction in heating fuel use through heat recovery has the potential to save 47 kt of CO2 eq. or £7.4 M per annum in United Kingdom malt whisky production alone, based on current fuel types used and current prices (2021).


Asunto(s)
Calor , Agua , Etanol , Cambio Climático , Carbono
12.
Front Insect Sci ; 3: 1180568, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-38469473

RESUMEN

Integrated pest management (IPM) strategies are being promoted to suppress tephritid fruit fly infestation and reduce economic damage in mango production. However, research on their economic performance across different mango production scales (measured by the number of mango trees) is limited. This study estimated the economic benefits of IPM practices (parasitoids, orchard sanitation, food bait, biopesticides, male annihilation technique, and their combinations) in Kenya's small-, medium-, and large-scale mango production systems. We used the value-cost ratio (VCR) and net present value methods to estimate the heterogeneous economic performance of IPM practices using data from two unique farm surveys. On average, all IPM practices were profitable across various production scales. However, we found that these practices were more profitable for medium-scale farmers than for small- and large-scale farmers. The results show that farmers need a minimum of 9-17 trees, depending on the practice used, to break even and that there are little to no economic benefits to using IPM practices for farmers with more than 320 mango trees. The male annihilation technique was the most profitable practice, with a VCR of 36, and consequentially, the most adopted practice across all scales of production. Overall, we found significant heterogeneity in the profitability of IPM practices across different scales of production. The reason for the lack of profitability of IPM on large-scale farms remains unclear and warrants further investigation.

13.
Sustainability ; 14(19): 1-33, 2022 Sep 27.
Artículo en Inglés | MEDLINE | ID: mdl-36406588

RESUMEN

Riparian buffer zones (RBZs) have been shown to be effective best management practices (BMPs) in controlling non-point source pollutants in waterbodies. However, the holistic sustainability assessment of individual RBZ designs is lacking. We present a methodology for evaluating the holistic sustainability of RBZ policy scenarios by integrating environmental and economic indicators simulated in three watersheds in the southeastern USA. We developed three unique sets of 40, 32, and 48 RBZ policy scenarios as decision management objectives (DMOs), respectively, in Back Creek, Sycamore Creek, and Greens Mill Run watersheds (Virginia and North Carolina) by combining the RBZ-widths with vegetation types (grass, urban, naturalized, wildlife, three-zone forest, and two-zone forest). We adapted the RBZ-hydrologic and water quality system assessment data of instream water quality parameters (dissolved oxygen, total phosphorus, total nitrogen, total suspended solids-sediment and biochemical oxygen demand) as environmental indicators, recently published by U.S. EPA. We calculated 20-year net present value costs as economic indicators using the RBZ's establishment, maintenance, and opportunity costs data published by the Natural Resources Conservation Service. The mean normalized net present value costs varied by DMOs ranging from 4% (grass RBZ-1.9 m) to 500% (wildlife RBZ-91.4 m) across all watersheds, due primarily to the width and the opportunity costs. The mean normalized environmental indicators varied by watersheds, with the largest change in total nitrogen due to urban RBZs in Back Creek (60-95%), Sycamore Creek (37-91%), and Greens Mill (52-93%). The holistic sustainability assessments revealed the least to most sustainable DMOs for each watershed, from least sustainable wildlife RBZ (score of 0.54), three-zone forest RBZ (0.32), and three-zone forest RBZ (0.62), respectively, for Back Creek, Sycamore Creek, and Greens Mill, to most sustainable urban RBZ (1.00) for all watersheds.

14.
Data Brief ; 44: 108485, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35966950

RESUMEN

This data article contains the location, energy consumption, renewable energy potential, techno-economics, and profitability of hybrid renewable energy systems (HRES) in 634 Philippine off-grid islands. The HRES under consideration consists of solar photovoltaics, wind turbines, lithium-ion batteries, and diesel generators. The islands were identified from Google Maps™, Bing Maps™, and the study of Meschede and Ocon et al. (2019) [1]. The peak loads of these islands were acquired from National Power Corporation - Small Power Utilities Group (NPC-SPUG), if available, or estimated from the island population otherwise. Hourly-resolution load profiles were synthesized using the normalized profiles reported by Bertheau and Blechinger (2018) [2]. Existing diesel generators in the islands were compiled from reports by NPC-SPUG, while monthly average global horizontal irradiance and wind speeds were taken from the Phil-LIDAR 2 database. Islands that are electrically interconnected were lumped into one microgrid, so the 634 islands were grouped into 616 microgrids. The HRES were optimized using Island System LCOEmin Algorithm (ISLA), our in-house energy systems modeling tool, which sized the energy components to minimize the net present cost. The component sizes and corresponding techno-economic metrics of the optimized HRES in each microgrid are included in the dataset. In addition, the net present value, internal rate of return, payback period, and subsidy requirements of the microgrid are reported at five different electricity rates. This data is valuable for researchers, policymakers, and stakeholders who are working to provide sustainable energy access to off-grid communities. A comprehensive analysis of the data can be found in our article "Techno-economic and Financial Analyses of Hybrid Renewable Energy System Microgrids in 634 Philippine Off-grid Islands: Policy Implications on Public Subsidies and Private Investments" [3].

15.
Glob Chall ; 6(7): 2100108, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-35860394

RESUMEN

This research entails the simulation of three possible power scenarios for Kenya from 2015 to 2035 using low emissions analysis platform (LEAP). These scenarios represent the unfolding future electricity generation that will fully satisfy the demand while considering the following: energy security, power generation cost, and impacts on the environment. These scenarios are reference scenario (RS), coal scenario (CS), nuclear scenario (NS), and more renewable scenario (MRS). The findings obtained reveals that the most sustainable scenario while comparing the costs was found to be the coal scenario with a net present value (NPV) of $30 052.67 million though it has the highest greenhouse gases (GHGs) emissions. However, the more renewable scenario (MRS) has the least GHGs emissions but is found to be the most expensive scenario to implement with an NPV of $30 733.07 million.

16.
G3 (Bethesda) ; 12(8)2022 07 29.
Artículo en Inglés | MEDLINE | ID: mdl-35652749

RESUMEN

Look-ahead selection is a sophisticated yet effective algorithm for genomic selection, which optimizes not only the selection of breeding parents but also mating strategy and resource allocation by anticipating the implications of crosses in a prespecified future target generation. Simulation results using maize datasets have suggested that look-ahead selection is able to significantly accelerate genetic gain in the target generation while maintaining genetic diversity. In this paper, we propose a new algorithm to address the limitations of look-ahead selection, including the difficulty in specifying a meaningful deadline in a continuous breeding process and slow growth of genetic gain in early generations. This new algorithm uses the present value of genetic gains as the breeding objective, converting genetic gains realized in different generations to the current generation using a discount rate, similar to using the interest rate to measure the time value of cash flows incurred at different time points. By using the look-ahead techniques to anticipate the future gametes and thus present value of future genetic gains, this algorithm yields a better trade-off between short-term and long-term benefits. Results from simulation experiments showed that the new algorithm can achieve higher genetic gains in early generations and a continuously growing trajectory as opposed to the look-ahead selection algorithm, which features a slow progress in early generations and a growth spike right before the deadline.


Asunto(s)
Fitomejoramiento , Selección Genética , Simulación por Computador , Genoma , Genómica , Modelos Genéticos
17.
Expert Rev Pharmacoecon Outcomes Res ; 22(6): 993-1011, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35488437

RESUMEN

BACKGROUND: Selection of a biosimilar development candidate requires detailed and careful analysis to ensure value creation. RESEARCH DESIGN AND METHODS: We applied the net present value (NPV) model for financial evaluation of biosimilar development candidates for the global market. Biosimilar development candidates from three categories were identified based on the global sales of their respective original biological products (OBPs): >$1 and ≤$4 billion, >$4 and ≤$7 billion and >$7 and ≤$10 billion. The standard NPV and risk-adjusted NPV (rNPV) were calculated under the base-case and various scenarios related to development costs, sales, selling, general and administrative expense, cost of goods sold, and discount rates. RESULTS: A biosimilar to an OBP with sales of $1.6 billion has some financial risk. Biosimilars to OBPs with sales of $5.5 billion and $9.4 billion have very less financial risk under the base-case scenario of analysis. Sales of an OBP had impact on the financial valuation and attractiveness of a biosimilar. Sensitivity of rNPV to different parameters varied for three biosimilars. Discount rates, sales and development costs were important parameters affecting financial valuation of biosimilars. CONCLUSION: Biosimilar development candidate selection requires a thorough financial evaluation considering product-, company- and market-specific aspects.


Asunto(s)
Biosimilares Farmacéuticos , Humanos
18.
Environ Sci Pollut Res Int ; 29(23): 35073-35095, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35044606

RESUMEN

Bangladesh government is in the final stage of setting up one nuclear power plant with two units at Rooppur, Ishwardi, each having 1200 MW capacity, to be launched in 2023 to meet the energy shortage urgently. The financial cost of the project is the US $12.65 billion. The primary purpose of this paper is to calculate the economic cost of setting up this plant by using the estimation method developed by Du and Parsons (2009), MIT (2003; 2009; 2018), and Singh et al.  (2018). It has been found that the economic cost is amounted to 9.36 cents/kWh for the capacity of 2400 MW. In contrast, for a similar plant in Kudankulam, Tamil Nadu, India, the corresponding cost figure is 5.36 cents/kWh for 2000 MW. Even though it seems costlier than India, the study suggests that policymakers should prefer nuclear power, as it is cost-competitive, considering the production cost of other electricity facilities. The main advantage of nuclear power is cost-competitive baseload power generation with zero carbon emission. This nuclear power plant (NPP) project is expected to boost the energy sector of Bangladesh by transforming the country from an energy deficit country into an energy surplus country.


Asunto(s)
Electricidad , Plantas de Energía Nuclear , Bangladesh , Dióxido de Carbono/análisis , India , Centrales Eléctricas
19.
Renew Sustain Energy Rev ; 153: 111786, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-34690528

RESUMEN

Combating the COVID-19 pandemic has raised the demand for and disposal of personal protective equipment in the United States. This work proposes a novel waste personal protective equipment processing system that enables energy recovery through producing renewable fuels and other basic chemicals. Exergy analysis and environmental assessment through a detailed life cycle assessment approach are performed to evaluate the energy and environmental sustainability of the processing system. Given the environmental advantages in reducing 35.42% of total greenhouse gas emissions from the conventional incineration and 43.50% of total fossil fuel use from landfilling processes, the optimal number, sizes, and locations of establishing facilities within the proposed personal protective equipment processing system in New York State are then determined by an optimization-based site selection methodology, proposing to build two pre-processing facilities in New York County and Suffolk County and one integrated fast pyrolysis plant in Rockland County. Their optimal annual treatment capacities are 1,708 t/y, 8,000 t/y, and 9,028 t/y. The proposed optimal personal protective equipment processing system reduces 31.5% of total fossil fuel use and 35.04% of total greenhouse gas emissions compared to the personal protective equipment incineration process. It also avoids 41.52% and 47.64% of total natural land occupation from the personal protective equipment landfilling and incineration processes.

20.
Entramado ; 17(2): 24-40, jul.-dic. 2021. tab, graf
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1360412

RESUMEN

RESUMEN El objetivo es desarrollar un modelo de planeación financiera que permita calcular las ganancias probables de una compañía de alimentos en Colombia, en un horizonte temporal de seis años. La metodología utilizada es el Valor Presente Neto de sus flujos de caja libre, calculados a partir de 38 variables de entrada y de proceso que recogen el aspecto macroeconómico, las políticas financieras y los estados contables. Se realizaron 10.000 iteraciones con la técnica de simulación Montecarlo. Los resultados de la simulación indican que sus ganancias probables están entre $278.293 millones y $449.934 millones con un nivel de confianza del 90%. El análisis de sensibilidad del plan financiero permite concluir que la compañía debe reformular sus políticas financieras relacionadas con la administración del capital de trabajo, dado que la cartera y principalmente los inventarios tienen una influencia negativa sobre el VPN, según los coeficientes de regresión. CLASIFICACIÓN JEL B41, C15


ABSTRACT The goal is to develop a financial planning model that allows calculating the probable profits of a food company in Colombia, in a time horizon of six years. The methodology used is the Net Present Value of its Free Cash Flow, calculated from 38 input and process variables that include the macroeconomic aspect, financial policies and financial statements. 10.000 iterations were carried out with the Montecarlo simulation technique. The simulation results indicate that its probable profits are between $278.293 million and y $449.934 million with a confidence level of 90%. The sensitivity analysis of the financial plan allows to conclude that the company should reformulate its financial policies related to the management of working capital, since the debt clients and mainly the inventories has a negative influence on the Net Present Value, according the regression coefficients. JEL CLASSIFICATION B41, C15


RESUMO O objectivo é desenvolver um modelo de planeamento financeiro que permita calcular os prováveis lucros de uma empresa alimentar na Colômbia, num horizonte temporal de seis anos. A metodologia utilizada é o Valor Presente Líquido dos seus fluxos de caixa livres, calculado a partir de 38 variáveis de entrada e de processo que recolhem o aspecto macroeconómico, as políticas financeiras e as declarações contabilísticas. Um total de 10.000 iterações foram realizadas utilizando a técnica de simulação de Monte Carlo. Os resultados da simulação indicam que os seus prováveis lucros se situam entre $278,293 milhões e $449,934 milhões com um nível de confiança de 90%. A análise de sensibilidade do plano financeiro permite concluir que a empresa deve reformular as suas políticas financeiras relacionadas com a gestão do capital de exploração, uma vez que a carteira e principalmente os inventários têm uma influência negativa no VPL, de acordo com os coeficientes de regressão. CLASSIFICAÇÃO JEL B4I, CI5

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